Category Archives: Design

14. Great and Not so Great Designs

Common Designs to Reduce Error Variance Contra-lateral Design This is a very sweet type of study design, but it can be seldom used in pharma or biotech.  Devices are another story.  With only one group (rather than two) and the … Continue reading

Posted in Analysis of Covariance, Contra-lateral, Crossover, Design, Effect Size, Parallel Group | Leave a comment

22. A question on QoL, Percentage Change from Baseline, and Compassionate-Usage Protocols

Yesterday was 1 degree Fahrenheit and today is 10.  I’m ten times warmer!! Compassion?  We statisticians have evolved beyond such petty human affects. I received the following question from Simon Wilkinson from New Zealand:  Dear Allen. To set the scene, … Continue reading

Posted in Confidence intervals, Design, Interval, Nominal, Ordinal, percentage change from baseline, Statistics, Treatment Effect | 4 Comments

23. Small N study to publish or not?

The following question was sent to me, I thought it useful enough for a full elaboration: Submitted on 2014/05/12 at 8:23 am Dr. Fleishman, I am so happy I found your site. I have been trying to decide how to best … Continue reading

Posted in assumptions, Confidence intervals, Design, Effect Size, non-parametric statistics, Ordinal, p-values, Parallel Group, Power, t-test, Treatment Effect | 1 Comment

24. Simple, but Simple-Minded

Science is organized common sense where many a beautiful theory was killed by an ugly fact. – Thomas Huxley It really is a nice theory.  The only defect I can think it has is probably common to all philosophical theories. … Continue reading

Posted in assumptions, Design, percentage change from baseline, Statistics, Treatment Effect | 4 Comments

27. Number of Events from Week x to Week y

What is your right shoe size?  What is your left shoe size? How many horses?  Simple, you count the number of hooves and divide by four. A man with one watch knows what time it is.  A man with two … Continue reading

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30. ‘Natural’ Herbs and Alternative Medicines

Just b’cause it ain’t science, don’t mean it ‘taint so. Phrenology, Four humors, You were cursed, Leeches, … ************************************ This blog is written for the general public, not for the pharma/device expert who is my typical target for my blog. My … Continue reading

Posted in Design, Uncategorized | Leave a comment