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 BioStatistical Blog
 1. Statistic’s Dirty Little Secret
 1.A Another view on testing by Peter Flom, PhD
 1.B Am I a nattering nabob of negativism?
 2. Why do we compute pvalues?
 3. Meaningful ways to determine the adequacy of a treatment effect when you have an intuitive knowledge of the dependent variable
 4. Meaningful ways to determine the adequacy of a treatment effect when you lack an intuitive knowledge of the dependent variable
 5. Accepting the null hypothesis
 6. ‘Lies, Damned Lies, and Statistics’ part 1, and Analysis Plans, an essential tool
 7. Assumptions of Statistical Tests
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Category Archives: Design
14. Great and Not so Great Designs
Common Designs to Reduce Error Variance Contralateral Design This is a very sweet type of study design, but it can be seldom used in pharma or biotech. Devices are another story. With only one group (rather than two) and the … Continue reading
22. A question on QoL, Percentage Change from Baseline, and CompassionateUsage Protocols
Yesterday was 1 degree Fahrenheit and today is 10. I’m ten times warmer!! Compassion? We statisticians have evolved beyond such petty human affects. I received the following question from Simon Wilkinson from New Zealand: Dear Allen. To set the scene, … Continue reading
23. Small N study to publish or not?
The following question was sent to me, I thought it useful enough for a full elaboration: Submitted on 2014/05/12 at 8:23 am Dr. Fleishman, I am so happy I found your site. I have been trying to decide how to best … Continue reading
24. Simple, but SimpleMinded
Science is organized common sense where many a beautiful theory was killed by an ugly fact. – Thomas Huxley It really is a nice theory. The only defect I can think it has is probably common to all philosophical theories. … Continue reading
27. Number of Events from Week x to Week y
What is your right shoe size? What is your left shoe size? How many horses? Simple, you count the number of hooves and divide by four. A man with one watch knows what time it is. A man with two … Continue reading
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30. ‘Natural’ Herbs and Alternative Medicines
Just b’cause it ain’t science, don’t mean it ‘taint so. Phrenology, Four humors, You were cursed, Leeches, … ************************************ This blog is written for the general public, not for the pharma/device expert who is my typical target for my blog. My … Continue reading
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