Category Archives: Key Comparison

8. What is a Power Analysis?

People who haven’t the time to do things ‘perfectly’, always have time to do them over. Measure once, cut twice.  Measure twice, cut once. ‘My god, you’ve conclusively proven it.  Time equals Money.’ *** Cost for Failure Every CEO I’ve … Continue reading

Posted in Biostatistics, Dichotomization, Effect Size, Key Comparison, Non-Inferiority, non-inferiority hypothesis, non-parametric statistics, noninferiority hypothesis, p-values, Power, Statistical, Statistics, Treatment Effect | Leave a comment

13. Multiple Observations and Statistical ‘Cheapies’

‘Measure once cut twice, measure twice cut once’ ‘A man with one watch knows what time it is, a man with two is never sure’ The three words which get everyone’s attention:  Free, Free, Free *** Multiple observations occur in … Continue reading

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17. Statistical Freebies/Cheapies – Multiple Comparisons and Adaptive Trials without self-immolation

If you shoot enough arrows, everyone can hit a bull’s-eye Free!   Free!  Free! BOGO – Buy One Get One Free *** Multiple Comparison Problem:  If you shoot at a target once and hit the bull’s-eye, then you’ve clearly hit your … Continue reading

Posted in Adaptive Trial, Interim Analysis, Key Comparison, Multiple Comparisons | 2 Comments