Category Archives: Multiple Comparisons

17. Statistical Freebies/Cheapies – Multiple Comparisons and Adaptive Trials without self-immolation

If you shoot enough arrows, everyone can hit a bull’s-eye Free!   Free!  Free! BOGO – Buy One Get One Free *** Multiple Comparison Problem:  If you shoot at a target once and hit the bull’s-eye, then you’ve clearly hit your … Continue reading

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31. Case History of a Trial

A colleague asked me to review a trial.  I will mask the identity of the trial and obfuscate irrelevant details, like the disease, timing, treatment, and key parameter. The patients had abnormal parathyroid glans, with hypercalcemia.  This was a Phase … Continue reading

Posted in Confidence intervals, Interim Analysis, Key Comparison, Multiple Comparisons, Uncategorized | Leave a comment